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The remaining 60 (9.4%) responses were classified as indifferent or concerned (this group was largely categorised by patients who were initially concerned but were no longer concerned)

If you start an injection and your fatigue suddenly worsens or you feel "wired," this is valuable information for your doctor

According to the NICE Clinical Knowledge Summary (CKS) and the British National Formulary (BNF) , the standard treatment for B12 deficiency without neurological symptoms involves: Hydroxocobalamin 1 mg intramuscularly three times weekly for two weeks Followed by maintenance doses of 1 mg every three months For patients with neurological symptoms (such as paraesthesia, numbness, cognitive changes, or gait disturbances), more intensive treatment is required: Hydroxocobalamin 1 mg intramuscularly on alternate days until no further improvement occurs Followed by 1 mg every two months for maintenance Pernicious anaemia , an autoimmune condition where the body cannot produce intrinsic factor, requires lifelong treatment

The in-vivo part of the study lasted 11 days